University of Minnesota
School of Physics & Astronomy
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Jochen Mueller

PAN 418 (office), 625-4369
PAN 487 (lab)
jochen @


Session Chair, 5th International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine (2002); Member of “Single cell / Single molecule” focus group as part of CBISC (Steering Committee of the Chemical Biology Initiative (2004); Panel Member, MPS-MCB Review, NSF (2004); Session Chair, 6th International Weber Symposium on Innovative Fluorescence Methodologies in Biochemistry and Medicine (2005); Panel Member, Biological Physics Review, NSF (2006); Member of the Graduate Research Advisory Committee (GRAC), Graduate School, University of Minnesota, (Spring 2006 – current); Organizer of Annual Hands-On Fluorescence Workshop for Students of Biological Sciences (2006 – 2010);

Summary of Interests
Experimental biophysics, two-photon excitation microscopy, fluorescence fluctuation spectroscopy

Selected Publications

J. P. Skinner, Y. Chen, and J. D. Mueller, Fluorescence Fluctuation Spectroscopy in the Presence of Immobile Fluorophores,", Biophys J (2008)

B. Wu, Y. Chen, and J. D. Mueller, Fluorescence Correlation Spectroscopy of Finite-Size Particles,”, Biophys J (2008)

B. P. Duckworth, Y. Chen, Y. Sham, J. D. Mueller, T. A. Taton, and M. D. Distefano, A Universal Method for the Preparation of Covalent Protein-DNA Conjugates for Use in Creating Protein Nanostructures,", Chem., Int. Ed.(2007)

Y. Chen and J. D. Müller, Determining the Stoichiometry of Protein Hetero-complexes in Living Cells with Fluorescence Fluctuation Spectroscopy,", Proc. Natl. Acad. Sci. USA (2007)

L. N. Hillesheim, Y. Chen, and J. D. Mueller, Dual-Color Photon Counting Histogram Analysis of mRFP1 and EGFP in Living Cells,", Biophys J (2006)

Y. Chen, M. Tekmen, L. N. Hillesheim, J. Skinner, B. Wu, and J. D. Müller, Dual-Color Photon Counting Histogram, Biophys. J. (accepted) 2005

M. Tekmen and J. D. Müller, High-Pressure Cell for Fluorescence Fluctuation Spectroscopy, Rev. Sci. Instr., 75, 5143-5148 (2004).

J. D. Müller, M. Tekmen, L. N. Hillesheim, W. Yang, and Y. Chen, Dual-Color Fluorescence Fluctuation Spectroscopy in vitro and in vivo, SPIE Proc. 5323, 136-145 (2004).

J. D. Müller, Cumulant analysis in fluorescence fluctuation spectroscopy, Biophys. J. 86(6), 3981-3992 (2004).

Y. Chen, L. N. Wei, and J. D. Müller , Probing protein oligomerization in living cells with fluorescence fluctuation spectroscopy, Proc. Natl. Acad. Sci. USA 100(26), 15492-15497 (2003).

L. N. Hillesheim and J. D. Müller, The Photon Counting Histogram in Fluorescence Fluctuation Spectroscopy with Non-ideal Photodectors, Biophys. J. 85, 1948-1958 (2003).

J. D. Müller, Following protein association in vivo with fluorescence fluctuation spectroscopy, SPIE Proc. 4963, 24-31 (2003).

J. D. Müller and E. Gratton, High-Pressure Fluorescence Correlation Spectroscopy, Biophys. J. 85(4), 2711-2719 (2003).


Ph.D., Technical University of Munich, 1997