University of Minnesota
School of Physics & Astronomy

Physics and Astronomy Calendar

Thursday, November 3rd 2016
3:35 pm:
Speaker: Vincent Noireaux
Subject: DNA programmed dynamical systems outside cells: from gene circuits to self-assembly
Refreshments to be served outside Keller 3-210 after the colloquium.

The analysis and characterization of complex dynamical interactions involved in gene regulation is a major theme in post-genomic research. Researchers from many different backgrounds have developed novel approaches to dissect gene network and to determine their basic principles.

In this talk I will present a unique cell-free platform that my lab has developed to construct complex information-based dynamical systems by executing gene circuits in vitro. The original goal was to prototype and to understand elementary regulatory gene networks in test tube reactions. Recently, we showed that our experimental platform is capable of recapitulating larger biochemical systems such as the complete synthesis of viruses that we use as a model of information to self-assembly process. Finally, I will show how we can execute gene circuits in synthetic liposomes to emulate biological functions in a synthetic cell analog.

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